Most people with advanced disease experience uncontrolled symptoms such as fatigue, pain or breathlessness, which can interfere with their daily lives. To help overcome these symptoms opioids are often prescribed for symptom relief to help patients, which enables them to do activities they were unable to do such as walking, climbing a flight of stairs and driving. Diana Ferreira discusses the importance for clinicians and researchers alike to critically consider the issues of driving and opioid use for people receiving palliative care.